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doi: 10.2196/19896, 43

Melanin is produced by specialized skin cells called melanocytes

GLP-1 (Glucagon-Like Peptide-1) An incretin hormone produced in the gut that reduces appetite through hypothalamic signaling, slows gastric emptying, and stimulates insulin secretion

Persistent bad breath can indicate underlying dental problems such as gum disease, tooth decay, oral infections, or tonsil stones that require professional treatment

Persistent constipation on semaglutide

Other Considerations Recent or planned major surgery : Due to effects on digestion and nutritional intake, these medications may not be appropriate around the time of major surgery